Zeljko Vujaskovic, MD, PhD

Education and Training

  • 1985, University of Zagreb School of Medicine, Croatia; MD
  • 1985-1986, Medical Centre, Karlovac, Croatia; internship
  • 1986-1987, Military Medical Academy, Belgrade, Serbia; residency
  • 1987-1989, Medical Centre, Karlovac, Croatia; residency
  • 1989-1990, University of Colorado Cancer Center, Fellowship, Medical Oncology; Denver, CO
  • 1990-1994, Colorado State University, Fort Collins, CO; Postdoctoral fellow, Radiological Health Sciences
  • 1994, Colorado State University, Fort Collins, CO; PhD

Biosketch

Zeljko Vujaskovic, MD, PhD, is a physician/scientist and professor who heads the Division of Translational Radiation Sciences in the Department of Radiation Oncology at the University of Maryland School of Medicine (UMSOM) in Baltimore. For more than 30 years, his career has been defined by transdisciplinary research that bridges the gap between basic science and clinical research to ultimately improve outcomes and long-term quality of life among cancer patients.

From 1999 to 2012 Dr. Vujaskovic served as a clinical radiation oncologist and director of the Normal Tissue Injury Laboratory at Duke University, where he was an associate professor of Radiation Oncology, Pathology, and Medical Physics. At Duke he also directed the Clinical Hyperthermia Program and served as associate director of the General Clinical Research Center. His laboratory focused on elucidating mechanisms underlying radiation injury and radiation therapy-induced toxicities in normal tissue. With his laboratory members, he published a series of seminal articles on tissue hypoxia and radiation exposure.

In 2012, Dr. Vujaskovic relocated his laboratory and clinical practice to the UMSOM to establish the new Division of Translational Radiation Sciences, with the mission to accelerate discovery and clinical implementation of new therapeutic strategies to improve tumor response in clinical radiotherapy, minimize postradiation therapy complications, and mitigate/treat the life-threatening health effects of a radioactive or nuclear agent. At Maryland, his lab has expanded to include more than 9,000 square feet of research space, with advanced instrumentation designed to rapidly move new therapeutic strategies along the continuum from development through approval to routine use. Research conducted in his laboratory has been funded by the National Institutes of Health, Department of Defense, Biomedical Advanced Research and Development Authority, private foundations, and industry, including Genzyme, MedImmune, Biogen, Amgen, Aeolus Pharmaceuticals, and others. The laboratory has earned an international reputation for excellence in developing and testing animal models of radiation injury and high-throughput assessment of compounds for potential radiomitigating properties.

Dr. Vujaskovic has published more than 150 articles and book chapters on radiation therapy, radiation injury, and hyperthermia topics. He has directed national and international research collaborations and is an active participant in cooperative group trials. He maintains an active clinical practice, with a focus on advanced treatment approaches in prostate cancer. He has recently assumed leadership of the Maryland Proton Alliance, a joint effort between UMSOM and the newly opened Maryland Proton Treatment Center in Baltimore, where, among other research initiatives, he plans to explore synergies between proton beam therapy and hyperthermia. In 2016 he was honored with the Society for Thermal Medicine’s J. Eugene Robinson Award, given each year to an investigator who has made outstanding contributions to hyperthermic oncology.

Research/Clinical Keywords

prostate cancer, radiation therapy, thermal therapy, radiation sciences, medical countermeasures

Highlighted Publications

Kimura M, Zodda AR, Mahmood J, Das SK, Nguyen GB, Jackson IL, Vujaskovic Z. Pilot study evaluating a rat model of radiation-induced erectile dysfunction using an image-guided microirradiator. Urology. 85(5):1214.e1-1214.e6, 2015.

Antonic V, Rabbani ZN, Jackson IL, Vujaskovic Z. Subcutaneous administration of bovine superoxide dismutase protects lungs from radiation-induced lung injury. Free Radic Res. 2015 Oct;49(10):1259-68.

Shukla HD, Mahmood J, Vujaskovic Z. Integrated proteo-genomic approach for early diagnosis and prognosis of cancer. Cancer Lett. 2015 Dec 1;369(1):28-36.

Snider JW 3rd, Datta NR, Vujaskovic Z. Hyperthermia and radiotherapy in bladder cancer. Int J Hyperthermia. 2016 Jun;32(4):398-406.

Xu PT, Maidment BW 3rd, Antonic V, Jackson IL, Das S, Zodda A, Zhang X, Seal S, Vujaskovic Z. Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice. Radiat Res. 2016 May;185(5):516-26.

Mahmood J, Zaveri SR, Murti SC, Alexander AA, Connors CQ, Shukla HD, Vujaskovic Z. Caveolin-1: a novel prognostic biomarker of radioresistance in cancer. Int J Radiat Biol. 2016 Sep 13:1-7. [Epub ahead of print]

  1. Vujaskovic, Z., Gillette, S. M., Powers, B. E., LaRue, S. M., Gillette, E. L., Borak, T. B., Scott, R. J.,  Colacchio, T. A. Intraoperative radiation (IORT) injury to sciatic nerve in a large aminal model. Radiotherapy and Oncology: journal of the European Society for Therapeutic Radiology and Oncology. 30:133-139; 1994.
  2. Vujaskovic, Z., Gillette, S. M., Powers, B. E., LaRue, S. M., Gillette, E. L., Borak, T. B., Scott, R. J., Ryan, T. P., Colacchio, T. A. Effects of intraoperative hyperthermia on peripheral nerves: neurological and electrophysiological studies. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 10:41-49; 1994.
  3. Vujaskovic, Z.,McChesney Gillette, S., Powers, B. E., Gillette, E. L., Scott, R. J., Whalen, R. L., Ryan, T. P., Colacchio, T. A. Effects of intraoperative hyperthermia on canine sciatic nerve: histopathologic and morphometric studies. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 10:845-855; 1994.
  4. Gillette, E. L., Mahler, P. A., Powers, B. E., Gillette, S. M., Vujaskovic, Z. Late radiation injury to muscle and peripheral nerves. International Journal of Radiation Oncology, Biology, Physics. 31:1309-1318; 1995.
  5. LaRue, S. M., Vujaskovic, Z. Combining radiation therapy with other treatment modalities. Seminars in Veterinary Medicine and Surgery. 10:197-204; 1995.
  6.  Vujaskovic, Z., Gillette, S. M., Powers, B. E., Thurmond, D. N., Gillette, E. L., Colacchio, T. A. Ultrastructural morphometric analysis of peripheral nerves after intraoperative irradiation. International journal of radiation biology. 68:71-76; 1995.
  7.  Vujaskovic, Z., Gillette, S. M., Powers, B. E., Stukel, T. A., Larue, S. M., Gillette, E. L., Borak, T. B., Scott, R. J., Weiss, J., Colacchio, T. A. Effects of intraoperative irradiation and intraoperative hyperthermia on canine sciatic nerve: neurologic and electrophysiologic study. International journal of radiation oncology, biology, physics. 34:125-131; 1996.
  8. van Waarde, M. A., van Assen, A. J., Kampinga, H. H., Konings, A. W., Vujaskovic, Z.Quantification of transforming growth factor-beta in biological material using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Analytical biochemistry. 247:45-51; 1997.
  9. Vujaskovic, Z. Structural and physiological properties of peripheral nerves after intraoperative irradiation. Journal of the peripheral nervous system: JPNS. 2:343-349; 1997.
  10. Vujaskovic, Z., Down, J. D., van Waarde, M. A., van Assen, A. J., Szabo, B. G., Konings, A. W. Plasma TGFbeta level in rats after hemithoracic irradiation. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 44:41-43; 1997.
  11. Sleijfer, S., Vujaskovic, Z., Limburg, P. C., SchraffordtKoops, H., Mulder, N. H. Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity. Cancer. 82:970-974; 1998.
  12.  Sminia, P., Barten, A. D., van Waarde, M. A., Vujaskovic, Z., van Tienhoven, G. Plasma transforming growth factor beta levels in breast cancer patients. Oncology Reports. 5:485-488; 1998.
  13. Vujaskovic, Z., Down, J. D., van t’ Veld, A. A., Mooyaart, E. L., Meertens, H., Piers, D. A., Szabo, B. G., Konings, A. W. Radiological and functional assessment of radiation-induced lung injury in the rat. Experimental lung research. 24:137-148; 1998.
  14.  Khouw, I. M., van Wachem, P. B., Plantinga, J. A., Vujaskovic, Z.,Wissink, M. J., de Leij, L. F., van Luyn, M. J. TGF-beta and bFGF affect the differentiation of proliferating porcine fibroblasts into myofibroblasts in vitro. Biomaterials. 20:1815-1822; 1999.
  15. Vujaskovic, Z., Powers, B. E., Paardekoper, G., Gillette, S. M., Gillette, E. L., Colacchio, T. A. Effects of intraoperative irradiation (IORT) and intraoperative hyperthermia (IOHT) on canine sciatic nerve: histopathological and morphometric studies. International journal of radiation oncology, biology, physics. 43:1103-1109; 1999.
  16. Poulson, J. M., Dewhirst, M. W., Gaskin, A. A., Vujaskovic, Z.,Samulski, T. V., Prescott, D. M., Meyer, R. E., Page, R. L., Thrall, D. E. Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs. In vivo. 14:709-714; 2000.
  17. Poulson, J. M., Vujaskovic, Z., Gillette, S. M., Chaney, E. L., Gillette, E. L. Volume and dose-response effects for severe symptomatic pneumonitis after fractionated irradiation of canine lung. International Journal of Radiation Biology. 76:463-468; 2000.
  18. Prescott, D. M., Charles, H. C., Poulson, J. M., Page, R. L., Thrall, D. E., Vujaskovic, Z., Dewhirst, M. W. The relationship between intracellular and extracellular pH in spontaneous canine tumors. Clinical cancer research: an official journal of the American Association for Cancer Research. 6:2501-2505; 2000.
  19. Van Putten, J. W., Schlosser, N. J., Vujaskovic, Z.,Leest, A. H., Groen, H. J. Superior vena cava obstruction caused by radiation induced venous fibrosis. Thorax. 55:245-246; 2000.
  20. Vujaskovic, Z.,Groen, H. J. TGF-beta, radiation-induced pulmonary injury and lung cancer. International journal of radiation biology. 76:511-516; 2000.
  21. Vujaskovic, Z., Marks, L. B., Anscher, M. S. The physical parameters and molecular events associated with radiation-induced lung toxicity. Seminars in radiation oncology. 10:296-307; 2000.
  22. Vujaskovic, Z., Poulson, J. M., Gaskin, A. A., Thrall, D. E., Page, R. L., Charles, H. C., MacFall, J. R., Brizel, D. M., Meyer, R. E., Prescott, D. M., Samulski, T. V., Dewhirst, M. W. Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment. International journal of radiation oncology, biology, physics. 46:179-185; 2000.
  23. van Eerde, M. R., Kampinga, H. H., Szabo, B. G., Vujaskovic, Z. Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 58:313-316; 2001.
  24. Vujaskovic, Z., Anscher, M. S., Feng, Q. F., Rabbani, Z. N., Amin, K., Samulski, T. S., Dewhirst, M. W., Haroon, Z. A. Radiation-induced hypoxia may perpetuate late normal tissue injury. International journal of radiation oncology, biology, physics. 50:851-855; 2001.
  25. Vujaskovic, Z.,Batinic-Haberle, I., Rabbani, Z. N., Feng, Q. F., Kang, S. K., Spasojevic, I., Samulski, T. V., Fridovich, I., Dewhirst, M. W., Anscher, M. S. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free radical biology & medicine. 33:857-863; 2002.
  26. Vujaskovic, Z.,Feng, Q. F., Rabbani, Z. N., Anscher, M. S., Samulski, T. V., Brizel, D. M. Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. Radiation research. 157:656-660; 2002.
  27. Vujaskovic, Z.,Feng, Q. F., Rabbani, Z. N., Samulski, T. V., Anscher, M. S., Brizel, D. M. Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. Experimental lung research. 28:577-590; 2002.
  28. Kang, S. K., Rabbani, Z. N., Folz, R. J., Golson, M. L., Huang, H., Yu, D., Samulski, T. S., Dewhirst, M. W., Anscher, M. S., Vujaskovic, Z. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International journal of radiation oncology, biology, physics. 57:1056-1066; 2003.
  29. Marks, L. B., Yu, X., Vujaskovic, Z., Small, W., Jr., Folz, R., Anscher, M. S. Radiation-induced lung injury. Seminars in radiation oncology. 13:333-345; 2003.
  30. Rabbani, Z. N., Anscher, M. S., Zhang, X., Chen, L., Samulski, T. V., Li, C. Y., Vujaskovic, Z. Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. International journal of radiation oncology, biology, physics. 57:563-572; 2003.
  31. Vujaskovic, Z., Rosen, E. L., Blackwell, K. L., Jones, E. L., Brizel, D. M., Prosnitz, L. R., Samulski, T. V., Dewhirst, M. W. Ultrasound guided pO2 measurement of breast cancer reoxygenation after neoadjuvant chemotherapy and hyperthermia treatment. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 19:498-506; 2003.
  32. Chen, L., Brizel, D. M., Rabbani, Z. N., Samulski, T. V., Farrell, C. L., Larrier, N., Anscher, M. S., Vujaskovic, Z.The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. International journal of radiation oncology, biology, physics. 60:1520-1529; 2004.
  33. Jones, E. L., Prosnitz, L. R., Dewhirst, M. W., Marcom, P. K., Hardenbergh, P. H., Marks, L. B., Brizel, D. M., Vujaskovic, Z.Thermochemoradiotherapy improves oxygenation in locally advanced breast cancer. Clinical cancer research: an official journal of the American Association for Cancer Research. 10:4287-4293; 2004.
  34. Kim, S. J., Rabbani, Z. N., Vollmer, R. T., Schreiber, E. G., Oosterwijk, E., Dewhirst, M. W., Vujaskovic, Z., Kelley, M. J. Carbonic anhydrase IX in early-stage non-small cell lung cancer. Clinical cancer research: an official journal of the American Association for Cancer Research. 10:7925-7933; 2004.
  35. Moeller, B. J., Cao, Y., Vujaskovic, Z., Li, C. Y., Haroon, Z. A., Dewhirst, M. W. The relationship between hypoxia and angiogenesis.Seminars in radiation oncology. 14:215-221; 2004.
  36. Poulson, J. M., Vujaskovic, Z., Gaskin, A. A., Larue, S. M., Meyer, R. E., Prescott, D. M., Samulski, T. V., Thrall, D. E., Dewhirst, M. W. Effect of calcitonin gene related peptide vs sodium nitroprusside to increase temperature in spontaneous canine tumours during local hyperthermia. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 20:477-489; 2004.
  37. Vujaskovic, Z., Song, C. W. Physiological mechanisms underlying heat-induced radiosensitization. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 20:163-174; 2004.
  38. Ward, E. R., Hedlund, L. W., Kurylo, W. C., Wheeler, C. T., Cofer, G. P., Dewhirst, M. W., Marks, L. B., Vujaskovic, Z. Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats. International journal of radiation oncology, biology, physics. 58:1562-1569; 2004.
  39. Zhang, X., Kon, T., Wang, H., Li, F., Huang, Q., Rabbani, Z. N., Kirkpatrick, J. P., Vujaskovic, Z., Dewhirst, M. W., Li, C. Y. Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer research. 64:8139-8142; 2004.
  40. Anscher, M. S., Chen, L., Rabbani, Z., Kang, S., Larrier, N., Huang, H., Samulski, T. V., Dewhirst, M. W., Brizel, D. M., Folz, R. J., Vujaskovic, Z. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. International journal of radiation oncology, biology, physics. 62:255-259; 2005.
  41. Anscher, M. S., Vujaskovic, Z. Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Seminars in oncology. 32:S86-91; 2005.
  42. Dewhirst, M. W., Poulson, J. M., Yu, D., Sanders, L., Lora-Michiels, M., Vujaskovic, Z., Jones, E. L., Samulski, T. V., Powers, B. E., Brizel, D. M., Prosnitz, L. R., Charles, H. C. Relation between pO2, 31P magnetic resonance spectroscopy parameters and treatment outcome in patients with high-grade soft tissue sarcomas treated with thermoradiotherapy. International journal of radiation oncology, biology, physics. 61:480-491; 2005.
  43. Dewhirst, M. W., Vujaskovic, Z., Jones, E., Thrall, D. Re-setting the biologic rationale for thermal therapy. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 21:779-790; 2005.
  44. Hardee, M. E., Kirkpatrick, J. P., Shan, S., Snyder, S. A., Vujaskovic, Z.,Rabbani, Z. N., Dewhirst, M. W., Blackwell, K. L. Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. British journal of cancer. 93:1350-1355; 2005.
  45. Hart, J. P., Broadwater, G., Rabbani, Z., Moeller, B. J., Clough, R., Huang, D., Sempowski, G. A., Dewhirst, M., Pizzo, S. V., Vujaskovic, Z.,Anscher, M. S. Cytokine profiling for prediction of symptomatic radiation-induced lung injury. International journal of radiation oncology, biology, physics. 63:1448-1454; 2005.
  46. Howard, B. A., Furumai, R., Campa, M. J., Rabbani, Z. N., Vujaskovic, Z., Wang, X. F., Patz, E. F., Jr. Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo. Cancer research. 65:8853-8860; 2005.
  47. Jones, E. L., Oleson, J. R., Prosnitz, L. R., Samulski, T. V., Vujaskovic, Z., Yu, D., Sanders, L. L., Dewhirst, M. W. Randomized trial of hyperthermia and radiation for superficial tumors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 23:3079-3085; 2005.
  48. Jones, E. L., Prosnitz, L. R., Dewhirst, M. W., Vujaskovic, Z.,Samulski, T. V., Oleson, J. R., Yu, D., Myerson, R. J., Moros, E. G., Hurwitz, M. D., Bull, J. M. In regard to Vasanathan et al. (Int J RadiatOncolBiolPhys 2005;61:145-153). International journal of radiation oncology, biology, physics. 63:644; 2005.
  49. Kim, S. J., Rabbani, Z. N., Dewhirst, M. W., Vujaskovic, Z., Vollmer, R. T., Schreiber, E. G., Oosterwijk, E., Kelley, M. J. Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung cancer. 49:325-335; 2005.
  50. Moeller, B. J., Batinic-Haberle, I., Spasojevic, I., Rabbani, Z. N., Anscher, M. S., Vujaskovic, Z., Dewhirst, M. W. A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. International journal of radiation oncology, biology, physics. 63:545-552; 2005.
  51. Rabbani, Z. N., Anscher, M. S., Folz, R. J., Archer, E., Huang, H., Chen, L., Golson, M. L., Samulski, T. S., Dewhirst, M. W., Vujaskovic, Z. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC cancer. 5:59; 2005.
  52. Schroeder, T., Yuan, H., Viglianti, B. L., Peltz, C., Asopa, S., Vujaskovic, Z., Dewhirst, M. W. Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. Cancer research. 65:5163-5171; 2005.
  53. Anscher, M. S., Garst, J., Marks, L. B., Larrier, N., Dunphy, F., Herndon, J. E., 2nd, Clough, R., Marino, C., Vujaskovic, Z., Zhou, S., Dewhirst, M. W., Shafman, T. D., Crawford, J. Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury. International journal of radiation oncology, biology, physics. 66:477-482; 2006.
  54. Anscher, M. S., Thrasher, B., Rabbani, Z., Teicher, B., Vujaskovic, Z.Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. International journal of radiation oncology, biology, physics. 65:876-881; 2006.
  55. Batinic-Haberle, I., Spasojevic, I., Stevens, R. D., Bondurant, B., Okado-Matsumoto, A., Fridovich, I., Vujaskovic, Z., Dewhirst, M. W. New PEG-ylatedMn(III) porphyrins approaching catalytic activity of SOD enzyme. Dalton transactions. 617-624; 2006.
  56. Dressman, H. K., Hans, C., Bild, A., Olson, J. A., Rosen, E., Marcom, P. K., Liotcheva, V. B., Jones, E. L., Vujaskovic, Z., Marks, J., Dewhirst, M. W., West, M., Nevins, J. R., Blackwell, K. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clinical cancer research: an official journal of the American Association for Cancer Research. 12:819-826; 2006.
  57. Hardee, M. E., Rabbani, Z. N., Arcasoy, M. O., Kirkpatrick, J. P., Vujaskovic, Z.,Dewhirst, M. W., Blackwell, K. L. Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity. Molecular cancer therapeutics. 5:356-361; 2006.
  58. Jackson, I. L., Batinic-Haberle, I., Sonveaux, P., Dewhirst, M. W., Vujaskovic, Z. ROS production and angiogenic regulation by macrophages in response to heat therapy. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 22:263-273; 2006.
  59. Jones, E., Alvarez Secord, A., Prosnitz, L. R., Samulski, T. V., Oleson, J. R., Berchuck, A., Clarke-Pearson, D., Soper, J., Dewhirst, M. W., Vujaskovic, Z. Intra-peritoneal cisplatin and whole abdomen hyperthermia for relapsed ovarian carcinoma. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 22:161-172; 2006.
  60. Jones, E., Thrall, D., Dewhirst, M. W., Vujaskovic, Z. Prospective thermal dosimetry: the key to hyperthermia’s future. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 22:247-253; 2006.
  61. Lora-Michiels, M., Yu, D., Sanders, L., Poulson, J. M., Azuma, C., Case, B., Vujaskovic, Z., Thrall, D. E., Charles, H. C., Dewhirst, M. W. Extracellular pH and P-31 magnetic resonance spectroscopic variables are related to outcome in canine soft tissue sarcomas treated with thermoradiotherapy. Clinical Cancer Research: an official journal of the American Association for Cancer Research. 12:5733-5740; 2006.
  62. Mi, J., Zhang, X., Rabbani, Z. N., Liu, Y., Su, Z., Vujaskovic, Z.,Kontos, C. D., Sullenger, B. A., Clary, B. M. H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. Nucleic acids research. 34:3577-3584; 2006.
  63. Ponce, A. M., Vujaskovic, Z., Yuan, F., Needham, D., Dewhirst, M. W. Hyperthermia mediated liposomal drug delivery. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 22:205-213; 2006.
  64. Vlahovic, G., Rabbani, Z. N., Herndon, J. E., 2nd, Dewhirst, M. W., Vujaskovic, Z.Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-beta and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation. British Journal of Cancer. 95:1013-1019; 2006.
  65. Fleckenstein, K., Gauter-Fleckenstein, B., Jackson, I. L., Rabbani, Z., Anscher, M., Vujaskovic, Z. Using biological markers to predict risk of radiation injury. Seminars in Radiation Oncology. 17:89-98; 2007.
  66. Fleckenstein, K., Zgonjanin, L., Chen, L., Rabbani, Z., Jackson, I. L., Thrasher, B., Kirkpatrick, J., Foster, W. M., Vujaskovic, Z. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. International journal of radiation oncology, biology, physics. 68:196-204; 2007.
  67. Hardee, M. E., Cao, Y., Fu, P., Jiang, X., Zhao, Y., Rabbani, Z. N., Vujaskovic, Z.,Dewhirst, M. W., Arcasoy, M. O. Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. PLOS one. 2:e549; 2007.
  68. Jackson, I. L., Chen, L., Batinic-Haberle, I., Vujaskovic, Z. Superoxide dismutase mimetic reduces hypoxia-induced O2*-, TGF-beta, and VEGF production by macrophages. Free radical research. 41:8-14; 2007.
  69. Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujaskovic, Z.,Dewhirst, M. W., Li, C. Y. Regulation of HIF-1alpha stability through S-nitrosylation. Molecular cell. 26:63-74; 2007.
  70. Oldham, M., Sakhalkar, H., Wang, Y. M., Guo, P., Oliver, T., Bentley, R., Vujaskovic, Z., Dewhirst, M. Three-dimensional imaging of whole rodent organs using optical computed and emission tomography. Journal of biomedical optics.12:014009; 2007.
  71. Rabbani, Z. N., Batinic-Haberle, I., Anscher, M. S., Huang, J., Day, B. J., Alexander, E., Dewhirst, M. W., Vujaskovic, Z. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. International journal of radiation oncology, biology, physics. 67:573-580; 2007.
  72. Rabbani, Z. N., Salahuddin, F. K., Yarmolenko, P., Batinic-Haberle, I., Thrasher, B. A., Gauter-Fleckenstein, B., Dewhirst, M. W., Anscher, M. S., Vujaskovic, Z. Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free radical research. 41:1273-1282; 2007.
  73. Vlahovic, G., Ponce, A. M., Rabbani, Z., Salahuddin, F. K., Zgonjanin, L., Spasojevic, I., Vujaskovic, Z., Dewhirst, M. W. Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts. British journal of cancer. 97:735-740; 2007.
  74. Vujaskovic, Z., Thrasher, B. A., Jackson, I. L., Brizel, M. B., Brizel, D. M. Radioprotective effects of amifostine on acute and chronic esophageal injury in rodents. International journal of radiation oncology, biology, physics. 69:534-540; 2007.
  75. Willett, C. G., Duda, D. G., di Tomaso, E., Boucher, Y., Czito, B. G., Vujaskovic, Z.,Vlahovic, G., Bendell, J., Cohen, K. S., Hurwitz, H. I., Bentley, R., Lauwers, G. Y., Poleski, M., Wong, T. Z., Paulson, E., Ludwig, K. A., Jain, R. K. Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer. Nature clinical practice. Oncology. 4:316-321; 2007.
  76. Anscher, M. S., Thrasher, B., Zgonjanin, L., Rabbani, Z. N., Corbley, M. J., Fu, K., Sun, L., Lee, W. C., Ling, L. E., Vujaskovic, Z. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. International journal of radiation oncology, biology, physics. 71:829-837; 2008.
  77. Gauter-Fleckenstein, B., Fleckenstein, K., Owzar, K., Jiang, C., Batinic-Haberle, I., Vujaskovic, Z. Comparison of two Mnporphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free radical biology & medicine. 44:982-989; 2008.
  78. Ghafoori, P., Marks, L. B., Vujaskovic, Z., Kelsey, C. R. Radiation-induced lung injury. Assessment, management, and prevention. Oncology. 22:37-47; discussion 52-33; 2008.
  79. Kirkpatrick, J. P., Rabbani, Z. N., Bentley, R. C., Hardee, M. E., Karol, S., Meyer, J., Oosterwijk, E., Havrilesky, L., Secord, A. A., Vujaskovic, Z., Dewhirst, M. W., Jones, E. L. Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomarker insights. 3:45-55; 2008.
  80. Sugahara, T., van der Zee, J., Kampinga, H. H., Vujaskovic, Z., Kondo, M., Ohnishi, T., Li, G., Park, H. J., Leeper, D. B., Ostapenko, V., Repasky, E. A., Watanabe, M., Song, C. W. Kadota Fund International Forum 2004. Application of thermal stress for the improvement of health, 15-18 June 2004, Awaji Yumebutai International Conference Center, Awaji Island, Hyogo, Japan. Final report. Int J Hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 24:123-140; 2008.
  81. van der Zee, J., Vujaskovic, Z., Kondo, M., Sugahara, T. The Kadota Fund International Forum 2004–clinical group consensus. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 24:111-122; 2008.
  82. Craciunescu, O. I., Blackwell, K. L., Jones, E. L., Macfall, J. R., Yu, D., Vujaskovic, Z., Wong, T. Z., Liotcheva, V., Rosen, E. L., Prosnitz, L. R., Samulski, T. V., Dewhirst, M. W. DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 25:405-415; 2009.
  83. Craciunescu, O. I., Stauffer, P. R., Soher, B. J., Wyatt, C. R., Arabe, O., Maccarini, P., Das, S. K., Cheng, K. S., Wong, T. Z., Jones, E. L., Dewhirst, M. W., Vujaskovic, Z.,MacFall, J. R. Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. Medical Physics. 36:4848-4858; 2009.
  84. Koontz, B. F., Vujaskovic, Z. Review: alcohol and other factors related to late prostate radiation injury. Clinical advances in hematology &oncology : H&O. 7:262; 2009.
  85. Kos, I., Reboucas, J. S., DeFreitas-Silva, G., Salvemini, D., Vujaskovic, Z., Dewhirst, M. W., Spasojevic, I., Batinic-Haberle, I. Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free radical biology & medicine. 47:72-78; 2009.
  86. Rabbani, Z. N., Spasojevic, I., Zhang, X., Moeller, B. J., Haberle, S., Vasquez-Vivar, J., Dewhirst, M. W., Vujaskovic, Z., Batinic-Haberle, I. Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free radical biology & medicine. 47:992-1004; 2009.
  87. Reboucas, J. S., Kos, I., Vujaskovic, Z.,Batinic-Haberle, I. Determination of residual manganese in Mnporphyrin-based superoxide dismutase (SOD) and peroxynitritereductase mimics. Journal of Pharmaceutical and Biomedical Analysis. 50:1088-1091; 2009.
  88. Viglianti, B. L., Lora-Michiels, M., Poulson, J. M., Lan, L., Yu, D., Sanders, L., Craciunescu, O., Vujaskovic, Z., Thrall, D. E., Macfall, J., Charles, C. H., Wong, T., Dewhirst, M. W. Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy. Clinical Cancer Research : an official journal of the American Association for Cancer Research. 15:4993-5001; 2009.
  89. Willett, C. G., Duda, D. G., di Tomaso, E., Boucher, Y., Ancukiewicz, M., Sahani, D. V., Lahdenranta, J., Chung, D. C., Fischman, A. J., Lauwers, G. Y., Shellito, P., Czito, B. G., Wong, T. Z., Paulson, E., Poleski, M., Vujaskovic, Z., Bentley, R., Chen, H. X., Clark, J. W., Jain, R. K. Efficacy, safety, and biomarkers of neoadjuvantbevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 27:3020-3026; 2009.
  90. Craciunescu, O. I., Thrall, D. E., Vujaskovic, Z., Dewhirst, M. W. Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:625-637; 2010.
  91. Dewhirst, M. W., Thrall, D. E., Palmer, G., Schroeder, T., Vujaskovic, Z., Cecil Charles, H., Macfall, J., Wong, T. Utility of functional imaging in prediction or assessment of treatment response and prognosis following thermotherapy. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:283-293; 2010.
  92. Gauter-Fleckenstein, B., Fleckenstein, K., Owzar, K., Jiang, C., Reboucas, J. S., Batinic-Haberle, I., Vujaskovic, Z. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radical Biology & Medicine. 48:1034-1043; 2010.
  93. Issels, R. D., Lindner, L. H., Verweij, J., Wust, P., Reichardt, P., Schem, B. C., Abdel-Rahman, S., Daugaard, S., Salat, C., Wendtner, C. M., Vujaskovic, Z.,Wessalowski, R., Jauch, K. W., Durr, H. R., Ploner, F., Baur-Melnyk, A., Mansmann, U., Hiddemann, W., Blay, J. Y., Hohenberger, P. Neo-adjuvant chemotherapy alone or with regional hyperthermia for localised high-risk soft-tissue sarcoma: a randomised phase 3 multicentre study. The Lancet Oncology. 11:561-570; 2010.
  94. Jackson, I. L., Vujaskovic, Z., Down, J. D. Revisiting strain-related differences in radiation sensitivity of the mouse lung: recognizing and avoiding the confounding effects of pleural effusions. Radiation Research. 173:10-20; 2010.
  95. Kim, S. J., Rabbani, Z. N., Dong, F., Vollmer, R. T., Schreiber, E. G., Dewhirst, M. W., Vujaskovic, Z., Kelley, M. J. Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer. Medical Oncology. 27:91-97; 2010.
  96. Kimura, M., Rabbani, Z., Mouraviev, V., Tsivian, M., Caso, J., Satoh, T., Baba, S., Vujaskovic, Z., Baust, J. M., Baust, J. G., Polascik, T. J. Role of vitamin D(3) as a sensitizer to cryoablation in a murine prostate cancer model: preliminary in vivo study. Urology. 76:764 e714-720; 2010.
  97. Kimura, M., Rabbani, Z., Mouraviev, V., Tsivian, M., Vujaskovic, Z., Satoh, T., Baba, S., Baust, J. M., Baust, J. G., Polascik, T. J. Morphology of hypoxia following cryoablation in a prostate cancer murine model: its relationship to necrosis, apoptosis and, microvessel density. Cryobiology. 61:148-154; 2010.
  98. Li, T., Zhu, X., Thongphiew, D., Lee, W. R., Vujaskovic, Z., Wu, Q., Yin, F. F., Wu, Q. J. On-line adaptive radiation therapy: feasibility and clinical study. Journal of Oncology.2010:407236; 2010.
  99. Rabbani, Z. N., Mi, J., Zhang, Y., Delong, M., Jackson, I. L., Fleckenstein, K., Salahuddin, F. K., Zhang, X., Clary, B., Anscher, M. S., Vujaskovic, Z. Hypoxia inducible factor 1alpha signaling in fractionated radiation-induced lung injury: role of oxidative stress and tissue hypoxia. Radiation Research. 173:165-174; 2010.
  100. Rampersaud, E. N., Vujaskovic, Z., Inman, B. A. Hyperthermia as a treatment for bladder cancer. Oncology. 24:1149-1155; 2010.
  101. Stauffer, P. R., Maccarini, P., Arunachalam, K., Craciunescu, O., Diederich, C., Juang, T., Rossetto, F., Schlorff, J., Milligan, A., Hsu, J., Sneed, P., Vujaskovic, Z.Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:686-698; 2010.
  102. Vujaskovic, Z., Kim, D. W., Jones, E., Lan, L., McCall, L., Dewhirst, M. W., Craciunescu, O., Stauffer, P., Liotcheva, V., Betof, A., Blackwell, K. A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:514-521; 2010.
  103. Yakovlev, V. A., Rabender, C. S., Sankala, H., Gauter-Fleckenstein, B., Fleckenstein, K., Batinic-Haberle, I., Jackson, I., Vujaskovic, Z.,Anscher, M. S., Mikkelsen, R. B., Graves, P. R. Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). Int J Radiation Oncology, Biology, Physics. 78:547-554; 2010.
  104. Zagar, T. M., Higgins, K. A., Miles, E. F., Vujaskovic, Z., Dewhirst, M. W., Clough, R. W., Prosnitz, L. R., Jones, E. L. Durable palliation of breast cancer chest wall recurrence with radiation therapy, hyperthermia, and chemotherapy. Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology. 97:535-540; 2010.
  105. Zagar, T. M., Oleson, J. R., Vujaskovic, Z., Dewhirst, M. W., Craciunescu, O. I., Blackwell, K. L., Prosnitz, L. R., Jones, E. L. Hyperthermia for locally advanced breast cancer. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:618-624; 2010.
  106. Zagar, T. M., Oleson, J. R., Vujaskovic, Z., Dewhirst, M. W., Craciunescu, O. I., Blackwell, K. L., Prosnitz, L. R., Jones, E. L. Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data. International journal of hyperthermia: the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 26:612-617; 2010.
  107. Batinic-Haberle, I., Rajic, Z., Tovmasyan, A., Reboucas, J. S., Ye, X., Leong, K. W., Dewhirst, M. W., Vujaskovic, Z., Benov, L., Spasojevic, I. Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics. Free Radical Biology & Medicine. 51:1035-1053; 2011.
  108. Beketic-Oreskovic, L., Ozretic, P., Rabbani, Z. N., Jackson, I. L., Sarcevic, B., Levanat, S., Maric, P., Babic, I., Vujaskovic, Z. Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in breast cancer patients. Pathology Oncology Research: POR. 17:593-603; 2011.
  109. Jackson, I. L., Vujaskovic, Z., Down, J. D. A further comparison of pathologies after thoracic irradiation among different mouse strains: finding the best preclinical model for evaluating therapies directed against radiation-induced lung damage. Radiation Research. 175:510-518; 2011.
  110. Kimura, M., Yan, H., Rabbani, Z., Satoh, T., Baba, S., Yin, F. F., Polascik, T. J., Donatucci, C. F., Vujaskovic, Z., Koontz, B. F. Radiation-induced erectile dysfunction using prostate-confined modern radiotherapy in a rat model. The Journal of Sexual Medicine. 8:2215-2226; 2011.
  111. Koontz, B. F., Yan, H., Kimura, M., Vujaskovic, Z.,Donatucci, C., Yin, F. F. Feasibility study of an intensity-modulated radiation model for the study of erectile dysfunction. The Journal of Sexual Medicine. 8:411-418; 2011.
  112. Li, T., Thongphiew, D., Zhu, X., Lee, W. R., Vujaskovic, Z., Yin, F. F., Wu, Q. J. Adaptive prostate IGRT combining online re-optimization and re-positioning: a feasibility study. Physics in Medicine and Biology. 56:1243-1258; 2011.
  113. Miriyala, S., Spasojevic, I., Tovmasyan, A., Salvemini, D., Vujaskovic, Z., St Clair, D., Batinic-Haberle, I. Manganese superoxide dismutase, MnSOD and its mimics. Biochimicaetbiophysicaacta. 2011.
  114. Spasojevic, I., Kos, I., Benov, L. T., Rajic, Z., Fels, D., Dedeugd, C., Ye, X., Vujaskovic, Z.,Reboucas, J. S., Leong, K. W., Dewhirst, M. W., Batinic-Haberle, I. Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. Free Radical Research. 45:188-200; 2011.
  115. Batinic-Haberle, I., Spasojevic, I., Tse, H. M., Tovmasyan, A., Rajic, Z., Clair, D. K., Vujaskovic, Z., Dewhirst, M. W., Piganelli, J. D. Erratum to: Design of Mnporphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino Acids. 42:115-116; 2012.
  116. Batinic-Haberle, I., Spasojevic, I., Tse, H. M., Tovmasyan, A., Rajic, Z., St Clair, D. K., Vujaskovic, Z., Dewhirst, M. W., Piganelli, J. D. Design of Mnporphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino Acids. 42:95-113; 2012.
  117. Kelsey, C. R., Jackson, L., Langdon, S., Owzar, K., Hubbs, J., Vujaskovic, Z., Das, S., Marks, L. B. A Polymorphism Within the Promoter of the TGFbeta1 Gene Is Associated With Radiation Sensitivity Using an Objective Radiologic Endpoint. International Journal of Radiation Oncology, Biology, Physics. 82:e247-255; 2012.
  118. Koontz, B. F., Tsivian, M., Mouraviev, V., Sun, L., Vujaskovic, Z., Moul, J., Lee, W. R. Impact of primary Gleason grade on risk stratification for Gleason score 7 prostate cancers. International Journal of Radiation Oncology, Biology, physics. 82:200-203; 2012.
  119. Stewart, S. B., Banez, L. L., Robertson, C. N., Freedland, S. J., Polascik, T. J., Xie, D., Koontz, B. F., Vujaskovic, Z., Lee, W. R., Armstrong, A. J., Febbo, P. G., George, D. J., Moul, J. W. Utilization trends at a multidisciplinary prostate cancer clinic: initial 5-year experience from the Duke Prostate Center. The Journal of Urology. 187:103-108; 2012.
  120. Betof, A. S., Rabbani, Z. N., Hardee, M. E., Kim, S. J., Broadwater, G., Bentley, R. C., Snyder, S. A., Vujaskovic, Z., Oosterwijk, E., Harris, L. N., Horton, J. K., Dewhirst, M. W., Blackwell, K. L. Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification. British J Cancer. 106:916-922; 2012
  121. Jackson, I. L., Zhang, X., Hadley, C., Rabbani, Z. N., Zhang, Y., Marks, S., Vujaskovic, Z. Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Free Radical Biology & Medicine. 53:337-346; 2012.
  122. Kimura, M., Caso, J. R., Banez, L. L., Koontz, B. F., Gerber, L., Senocak, C., Donatucci, C. F., Vujaskovic, Z., Moul, J. W., Polascik, T. J. Predicting participation in and successful outcome of a penile rehabilitation programme using a phosphodiesterase type 5 inhibitor with a vacuum erection device after radical prostatectomy. BJU Int. 2012.
  123. Kimura, M., Rabbani, Z. N., Zodda, A. R., Yan, H., Jackson, I. L., Polascik, T. J., Donatucci, C. F., Moul, J. W., Vujaskovic, Z., Koontz, B. F. Role of oxidative stress in a rat model of radiation-induced erectile dysfunction. The Journal of Sexual Medicine. 9:1535-1549; 2012.
  124. Yuan, Y., Cheng, K. S., Craciunescu, O. I., Stauffer, P. R., Maccarini, P. F., Arunachalam, K., Vujaskovic, Z., Dewhirst, M. W., Das, S. K. Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma. Medical Physics. 39:1170-1181; 2012
  125. Zhang, Y., Zhang, X., Rabbani, Z. N., Jackson, I. L., Vujaskovic, Z. Oxidative stress mediates radiation lung injury by inducing apoptosis. International Journal of Radiation Oncology, Biology, Physics. 83:740-748; 2012
  126. Jackson, I. L., Zhang, X., Hadley, C., Rabbani, Z. N., Zhang, Y., Marks, S., Vujaskovic, Z. Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Free Radic Biol Med. 53(2):337-46; 2012.
  127. Jackson, I.L., Xu, P., Hadley, C., Katz, B.P., McGurk, R., Down, J.D., Vujaskovic Z. A preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule. Health Phys. 103(4):463-473; 2012
  128. McGurk, R., Hadley, C., Jackson, I.L., Vujaskovic, Z. Development and dosimetry of a small animal lung irradiation platform. Health Phys. 103:454-462, 2012
  129. Zhou, S., Nissao, E., Jackson, I.L., Leong, W., Dancy, L., Cuttitta, F., Vujaskovic, Z., Sunday, M.E. Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide. Am J Pathol. 182:1248-1254; 2013
  130. Weitner, T., Kos, I., Sheng, H., Tovmasyan, A., Reboucas, J.S., Fan, P., Warner, D.S., Vujaskovic, Z., Batinic-Haberle, I., Spasojevic, I. Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. Free Radic Biol Med. 58:73-80; 2013
  131. Kelsey, C.R., Jackson, I.L., Langdon, S., Owzar, K., Hubbs, J., Vujaskovic, Z., Das, S., Marks, L.B. Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoint. Clin Lung Cancer. 14:267-274; 2013
  132. Tovmasyan, A., Sheng, H., Weitner, T., Arulpragasam, A., Lu, M., Warner, D.S., Vujaskovic, Z., Spasojevic, I., Batinic-Haberle, I. Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. Med Princ Pract. 22:103-130; 2013
  133. Koontz, B.F., Quaranta, B.P., Pura, J.A., Lee, W.R., Vujaskovic, Z., Gerber, L., Haake, M., Anscher, M.S., Robertson, C.N., Polascik, T.J., Moul, J.W. Phase 1 trial of neoadjuvant radiation therapy before prostatectomy for high-risk prostate cancer. Int J Radia Oncol Biol Phys. 87:88-93, 2013
  134. Down, J.D., Medhora, M., Jackson, I.L., Cline, J.M., Vujaskovic, Z. Do variations in mast cell hyperplasia account for differences in radiation-induced lung injury among different mouse strains, rats and nonhuman primates? Radiat Res. 180:216-221, 2013
  135. Jackson, I.L., Xu, P., Nguyen, G., Down, J.D., Johnson, C.S., Katz, B.P., Haley, C.C., Vujaskovic, Z. Characterization of the dose response relationship for lung injury following acute radiation exposure in three well-established murine strains: developing an interspecies bridge to link animal models with human lung. Health Phys. 106(1):48-55, 2014
  136. Jones, J.J., Scott, A.J., Tudor, G., Xu, P., Jackson, I.L., Vujaskovic, Z., Booth, C., MacVittie, T.J., Ernst, R.K., Kane, M.A. Identification and quantitation of biomarkers for radiation-induced injury via mass spectrometry. Health Phys. 106(1):106-119, 2014
  137. Batinic-Haberle, I., Tovmasyan, A., Roberts, E.R., Vujaskovic, Z., Leong, K.W., Spasojevic, I. SOD therapeutics: Latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal. 20(15):2372-2415, 2014
  138. Myerson, R.J., Moros, E.G., Diederich, C.J., Haemmerich, D., Hurwitz, M.D., Hsu, I.C., McGough, R.J., Nau, W.H., Straube, W.L., Turner, P.F., Vujaskovic, Z., Stauffer, P.R.          Components of a hyperthermia clinic: recommendations for staffing, equipment, and   treatment monitoring. International Journal of Hyperthermia. 30(1):1-5, 2014
  139. Gauter-Fleckenstein, B., Reboucas, J.S., Fleckenstein, K., Tovmasyan, A., Owzar, K., Jiang, C., Batinic-Haberle, I., Vujaskovic, Z. Robust rat pulmonary radioprotection by a        lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol. 2:400-410, 2014
  140. Inman, B.A., Stauffer, P.R., Craciunescu, O.A., Maccarini, P.F., Dewhirst, M.W., Vujaskovic, Z. A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer. International Journal of Hyperthermia. 30(3):171-175, 2014
  141. Juang, T., Stauffer, P.R., Craciunescu, O.A., Maccarini, P.F., Yuan, Y., Das, S.K., Dewhirst,                M.W., Inman, B.A., Vujaskovic, Z. Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer. International Journal of Hyperthermia. 30(3):176-83, 2014
  142. Zagar, T.M., Vujaskovic, Z., Formenti, S., Rugo, H., Muggia, F., O’Connor, B., Myerson, R., Stauffer, P., Hsu, I.-C., Diederich, C., Straube, W., Boss, M.-K., Boico, A., Craciunescu, O., Maccarini, P., Needham, D., Borys, N., Blackwell, K.L., Dewhirst, M.W. Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin    (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer. International Journal of Hyperthermia. 30(5):285-  294, 2014
  143. Kimura, M., Zodda, A.R., Mahmood, J., Das, S.K., Nguyen, G.B., Jackson, I.L., Vujaskovic, Z. Pilot study evaluating a rat model of radiation-induced erectile dysfunction using an image-guided microirradiator. Urology. 85(5):1214.e1-1214.e6, 2015
  144. Boggs DH, Guerrero M, Patel K, Chen S, Moeslein F, Amin P, Vujaskovic Z. Pelvic local recurrence in a patient with muscle-invasive bladder cancer treated with interstitial thermal therapy and interstitial brachytherapy. Pract Radiat Oncol. 2015 Sep-Oct;5(5):e483-7.
  145. Antonic V, Rabbani ZN, Jackson IL, Vujaskovic Z. Subcutaneous administration of bovine superoxide dismutase protects lungs from radiation-induced lung injury. Free Radic Res. 2015 Oct;49(10):1259-68.
  146. Shukla HD, Mahmood J, Vujaskovic Z. Integrated proteo-genomic approach for early diagnosis and prognosis of cancer. Cancer Lett. 2015 Dec 1;369(1):28-36.
  147. Murigi FN, Mohindra P, Hung C, Salimi S, Goetz W, Pavlovic R, Jackson IL, Vujaskovic Z. Dose Optimization Study of AEOL 10150 as a Mitigator of Radiation-Induced Lung Injury in CBA/J Mice. Radiat Res. 2015 Oct;184(4):422-32.
  148. Snider JW 3rd, Datta NR, Vujaskovic Z. Hyperthermia and radiotherapy in bladder cancer. Int J Hyperthermia. 2016 Jun;32(4):398-406.
  149. Xu PT, Maidment BW 3rd, Antonic V, Jackson IL, Das S, Zodda A, Zhang X, Seal S, Vujaskovic Z. Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice. Radiat Res. 2016 May;185(5):516-26.
  150. Zhang X, Hadley C, Jackson IL, Zhang Y, Zhang A, Spasojevic I, Haberle IB, Vujaskovic Z. Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung. Free Radic Res. 2016 Aug;50(8):875-86.
  151. Dabjan MB, Buck CM, Jackson IL, Vujaskovic Z, Marples B, Down JD. A survey of  changing trends in modelling radiation lung injury in mice: bringing out the good, the bad, and the uncertain. Lab Invest. 2016 Sep;96(9):936-49.
  152. Jones JW, Carter CL, Li F, Yu J, Pierzchalski K, Jackson IL, Vujaskovic Z, Kane MA. Ultraperformance convergence chromatography-high resolution tandem mass spectrometry for lipid biomarker profiling and identification. Biomed Chromatogr. 2016 Aug 24. [Epub ahead of print]
  153. Mahmood J, Zaveri SR, Murti SC, Alexander AA, Connors CQ, Shukla HD, Vujaskovic Z. Caveolin-1: a novel prognostic biomarker of radioresistance in cancer. Int J Radiat Biol. 2016 Sep 13:1-7. [Epub ahead of print]
  154. Zhang Y, Zanos P, Jackson I, Zhang X, Zhu X, Gould T, Vujaskovic Z. Psychological Stress Enhances Tumor Growth and Diminishes Radiation Response in Preclinical Model of Lung Cancer. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E474.
  155. Mahmood J, Murti SC, Zaveri SR, Shukla HD, Vujaskovic Z. Caveolin-1: A Novel  Prognostic Biomarker for Radioresistance in Non-Small Cell Lung Carcinoma (NSCLC) and Prostate Cancer. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E589-E590.
  156. Mahmood J, Shamah AA, Creed M, Pavlovic R, Matsui H, Eley J, Jackson I, Vujaskovic Z, Kimura M. Elucidation of the Molecular Mechanism of Radiation-Induced Erectile Dysfunction. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E591.

1992   Young Investigator Travel Award, The 6th International Congress on Hyperthermic Oncology, Tucson, Arizona

2009    R. Wayne Rundles Award, Duke Cancer Center

2016    J Eugene Robinson Award, The Society for Thermal Medicine Meeting, New Orleans, LA, 2016

Zeljko Vujaskovic, MD, PhD - Maryland Proton Treatment Center